The iceLogo web server and SOAP service for determining protein consensus sequences

he iceLogo web server and SOAP service implement the previously published iceLogo algorithm. iceLogo builds on probability theory to visualize protein consensus sequences in a format resembling sequence logos. Peptide sequences are compared against a reference sequence set that can be tailored to the studied system and the used protocol. As such, not only over-but also underrepresented residues can be visualized in a statistically sound manner, which further allows the user to easily analyse and interpret conserved sequence patterns in proteins. The web application and SOAP service can be found free and open to all users without the need for a login on http://iomics.ugent.be/icelogoserver/main.html

The Scottish economy [August 1984]

Throughout much of the last two years the official view has been that the Scottish recession was less severe than that experienced in the United Kingdom as a whole. Indeed, the Secretary of State has proclaimed to a variety of audiences, including the House of Commons, that Scotland was, and still is , leading the country out of recession. This diagnosis has not met with universal approval, as it appears to be founded primarily on the growth of the Scottish electronics sector and on the smaller proportionate rise in unemployment which has occurred in Scotland than in Britain as a whole. This latter fact is not particularly surprising as the pre-recession level of unemployment in Scotland was markedly above that of the rest of Britain

Outlook and appraisal [August 1984]

Growth in the British economy came almost to a halt during the first half of this year. As a result , even a speedy resolution of the coal dispute would be unlikely to push the GDP growth rate this year above 2.5 Though much of July's interest rate increase has already been reversed, it is likely to prove more difficult to reverse the effects on the retail price index and thus attain the goal of H.5% inflation at the end of the year. The uncompetitive nature of the housing finance market makes a speedy and full unwinding of the recent rise in mortgage rates unlikely

The influence of weather-type and long-range transport on airborne particle concentrations in Edinburgh, UK

This study investigated the influence of regional-scale synoptic weather type and geographical source regions of air masses on two-particle concentration metrics (Black Smoke (BS) and PM10) in the city of Edinburgh, UK, between 1981 and 1996. Twenty-seven classifications of Jenkinson Daily Weather Types (JWT) were subdivided into 9 directional categories and 3 vorticity categories, and the influence of JWT category on BS and PM10 determined. Four-day air mass back-trajectories for 1 July 1995–30 June 1996 were computed and grouped into 8 categories depending on the geographical route followed. Significantly elevated concentrations of BS (median values 2, 5 and 4 μg m−3 greater than median for 1981–1996) and PM10 (median values 3, 5.5 and 8 μg m−3 greater than median for 1992–1996) were observed for anticyclonic, southerly and south-easterly weather types, respectively. These differences were not identified at conventional levels of significance for BS in 1995– 1996. This may reflect a shift in more recent times to lower concentrations of predominantly locally emitted BS less affected by regional scale meteorology. Conversely, significant inter-trajectory category differences were observed for PM10 during 1995–1996, with highest concentrations associated with Eastern European trajectories and south-easterly weather type categories (11.4 and 10.7 μg m−3 greater than annual means, respectively). The variation in particle concentration across weather-type was a significant proportion of total median particle concentration, and of a magnitude associated with adverse health outcomes. Thus current PM10 concentrations (and associated health outcomes) in Edinburgh are likely to be significantly influenced by regional-scale meteorology independent of local air quality management areas. Furthermore, changes in long-term trends in distributions of synoptic weather types indicate that future climate change may influence exposure to PM10 and the PM10:BS ratio in Edinburgh. Further definition of the relationships between long-range transport and particle concentration will improve classification of human exposure in epidemiological studies

Review of the quarter's economic trends [May 1983]

The one thing this recovery does not lack is confidence. Surveys of business opinion in all the major economies reveal a greater level of optimism amongst the business community than at any time since 1979. But confidence alone is not adequate for a sustained recovery though it certainly helps. As this brief analysis shows, two constraints stand in the way of a worldwide upturn: real interest rates remain high and the response of governments to any acceleration of inflation remains unknown. The downward rigidity of nominal interest rates bears witness to the financial markets' belief that present low levels of inflation are not sustainable, yet if governments react to the expected mild acceleration of inflation in the latter half of this year with the policies of the recent past no significant recovery is likely. Further analysis of UK and world economic data are provided

Streetsport: Supporting and facilitating the development of enhanced graduate attributes.

Streetsport is a programme that aims to exercise social innovation by reducing instances of youth crime and anti-social behaviour; whilst promoting health and wellbeing through sport, physical activity and creative endeavour. As a vehicle for delivery the initiative facilitates work based educational experiences that are embedded within disadvantaged communities; supporting the development of enhanced graduate attributes by way of collaborative teaching and learning support. Adopting a collaborative partnership model, the programme brings together multiple courses, students and stakeholders to work within communities resulting in activities that react and respond to local needs, interests and demand

The impact of point mutations in the human androgen receptor : classification of mutations on the basis of transcriptional activity

Peer reviewedPublisher PD

Erratum to: Methods for evaluating medical tests and biomarkers

[This corrects the article DOI: 10.1186/s41512-016-0001-y.]